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Systemic administration: acute transmural myocardial infarction (not older than 12 hours), with persistent STsegment elevation or recent left bundle-branch block; deep vein thromboses (not older than 14 days); acute massive pulmonary embolism; acute and subacute thromboses of peripheral arteries; chronic occlusive arterial diseases (not older than 6 weeks); occlusion of central retinal artery or vein (arterial occlusions not older than 6 to 8 hours, venous occlusions not older than 10 days).
Local administration: acute myocardial infarction for re-opening of coronary vessels (not older than 12 hours); acute, subacute and chronic thromboses as well as embolisms of peripheral venous and arterial vessels.
Note: No statement on therapy outcome can be made for administration beyond the time windows indicated previously.
